Persuading natural killer cells to eliminate bad B cells.
نویسنده
چکیده
Clinical trials are underway infusing T cells genetically modified to be specific for B-cell malignancies using a chimeric antigen receptor (CAR) to redirect specificity for CD19. However, issues remain about whether the CAR can provide a fully competent application signal and whether other lymphocytes with lytic capacity can target CD19(+) tumors.
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عنوان ژورنال:
- Clinical cancer research : an official journal of the American Association for Cancer Research
دوره 15 15 شماره
صفحات -
تاریخ انتشار 2009